Universal Scaling in Mixing Correlated Growth with Randomness

We study two-component growth that mixes random deposition (RD) with a correlated growth process that occurs with probability p. We find that these composite systems are in the universality class of the correlated growth process. For RD blends with either Edwards-Wilkinson of Kardar-Parisi-Zhang processes, we identify a nonuniversal parameter in the universal scaling in p.Comment: 4 pages, 6 figures, 11 references; under revie

Comment on "Dynamic properties in a family of competitive growing models"

The article [Phys. Rev. E {\bf 73}, 031111 (2006)] by Horowitz and Albano reports on simulations of competitive surface-growth models RD+X that combine random deposition (RD) with another deposition X that occurs with probability $p$. The claim is made that at saturation the surface width $w(p)$ obeys a power-law scaling $w(p) \propto 1/p^{\delta}$, where $\delta$ is only either $\delta =1/2$ or $\delta=1$, which is illustrated by the models where X is ballistic deposition and where X is RD with surface relaxation. Another claim is that in the limit $p \to 0^+$, for any lattice size $L$, the time evolution of $w(t)$ generally obeys the scaling $w(p,t) \propto (L^{\alpha}/p^{\delta}) F(p^{2\delta}t/L^z)$, where $F$ is Family-Vicsek universal scaling function. We show that these claims are incorrect.Comment: 2 pages, 3 figures, accepted for publication in Physical Review E in Aug. 200

Discrete-Event Analytic Technique for Surface Growth Problems

We introduce an approach for calculating non-universal properties of rough surfaces. The technique uses concepts of distinct surface-configuration classes, defined by the surface growth rule. The key idea is a mapping between discrete events that take place on the interface and its elementary local-site configurations. We construct theoretical probability distributions of deposition events at saturation for surfaces generated by selected growth rules. These distributions are then used to compute measurable physical quantities. Despite the neglect of temporal correlations, our approximate analytical results are in very good agreement with numerical simulations. This discrete-event analytic technique can be particularly useful when applied to quantification problems, which are known to not be suited to continuum methods.Comment: 4 pages, 7 figures, published 17 Feb. 200

Update on Adverse Effects of HIV Integrase Inhibitors

PURPOSE OF REVIEW: The goal of this paper is to provide an up-to-date review of adverse events related to the class of integrase strand transfer inhibitors (INSTIs), which became the class of choice in few years. We sought answers specifically to issues pertaining to neuropsychiatric adverse events, as well as weight gain, which were the two most important categories of adverse events raised in recent studies based on real-life experience. The primary focus of this paper is on adults with a brief summary on pregnant women and children/adolescents. RECENT FINDINGS: Dolutegravir (DTG) bears the heaviest burden of neuropsychiatric side effects. Weight gain was reported with all INSTIs, although there are methodological caveats in the analyses and the findings need to be interpreted with caution. Moreover, due to recent findings on neural tube defects in infants exposed to dolutegravir during their peri-conception period, its use is not recommended for women of childbearing age without proper birth control method, while raltegravir remains the only drug which may be prescribed without caution. Given the importance of cognitive and metabolic co-morbidities in people living with HIV in regard to their quality of life, future research needs to focus on long-term effects of INSTIs in relation to these adverse events. Pharmacogenetics seems to be a promising tool. Safety during pregnancy is also another important issue to further clarify. SUMMARY: INSTIs are a generally well-tolerated class of antiretrovirals (ARV), and has a higher antiviral potency compared to other classes of ARV. Clinicians and patients need however to be aware of some red flags when starting with and monitoring patients on INSTIs. All INSTIs can lead to mild increases in creatinine levels, usually without clinical significance, but caution is needed in patients with low eGFR (<30ml/min), when using other nephrotoxic drugs, such as as tenofovir disoproxil. Neuro-psychiatric (NP) effects are to be monitored with INSTIs, especially with DTG (though reports are at times contradictory); clinicians might want to avoid DTG for patients with history of severe NP symptoms, until clarity is provided. Weight gain was reported with all INSTIs, especially with DTG, with possible differential effects according to sex and ethnicity (female and non-white patients being at increased risk). This is worrying since patients from African descent are at higher risk of cardio-vascular events and increased body mass index (BMI) can cause further increase metabolic risk. There is possibly an additional effect of tenofovir alafenamide (TAF) on weight increase. Discrepancies between clinical trials – with low rates of adverse events – and reports from real-life settings might be due partly to under-representation of some groups of patients in clinical trials, and/or the short duration of follow-up, since some adverse effects may only occur after prolonged exposure. Preliminary data on safety of bictegravir (BIC), from clinical trials and non-trial settings, are very reassuring and seem to show lower rates of adverse events compared to DTG. Elvitegravir/cobicistat (EVG/cobi) need to be used with caution in patients with other co-morbidities given potential for polypharmacy, as it is the case for aging patients, because of the high potential of drug-drug interactions due to effects of the cobicistat booster. We are awaiting the release of cabotegravir (CAB), which could represent a good option for patients struggling with adherence, despite injection site reactions. Pharmacogenetics is a promising way to explore adverse effects occurrence in the INSTI class